News – AU – UK and South African SARS-CoV-2 variants show higher binding affinity for the host cell receptor

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Public health officials are concerned about new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are occurring in various parts of the world

The B11Variant 7 was first found in the UK and has the N501Y mutation, which allows for a faster rate of transmission than previous strains

The B1The 351 variant was detected in South Africa and also has the genetic mutation N501Y observed in B117 However, scientists are also concerned about two other genetic mutations – K417N and E484K – that have shown the ability to evade the immune system. Previous evidence has the B. found1351 variant resistant to neutralizing antibodies produced by either prior infection or vaccination

Ongoing research is exploring how to slow the spread of these variants. Currently, the total number of COVID-19 cases worldwide has reached over 112 million. There are also more than 24 million deaths worldwide

To find the appropriate target to neutralize them, one has to understand how these variants become more deadly

New research from a team of scientists at Stanford University School of Medicine in the USAS found that both variants bind more closely to the human angiotensin converting enzyme 2 (ACE2) receptor.This receptor enables SARS-CoV-2 to penetrate host cells and infect them

The study results “SARS-CoV-2 B117 and B1351 spike variants bind human ACE2 with increased affinity “are available as a preprint on the bioRxiv * server while the article is being peer-reviewed

The team used an experimental tool called Microscale Thermophoresis to study how the B117 and B1351 variants become more infectious and, like the receptor binding domain of their spike proteins, interact with the human ACE2 protein

In particular, the receptor binding domain of B117 and B1351 was compared to the receptor binding domain of Hu-1 – the SARS-CoV-2 strain originally detected in Wuhan, China

The results showed a greater binding affinity between B.117s receptor binding domain and ACE2 compared to Hu-1 binding affinity B.117 showed a 198-fold higher affinity

The binding affinity for ACE2 was highest in B1351 variant There was a 462-fold higher affinity compared to Hu-1

These results suggest that the acquisition of increased affinity of spike proteins for the human ACE2 receptor may be a convergent trait of more transmissible SARS-CoV-2 variants that occur in multiple geographic regions and indicate that MST A quick route to biochemical evaluation of such changes offers ”

Based on the results, the researchers suggest that the results are consistent with previous models, which also attributed the increased transferability of both variants with greater binding affinity for human ACE2

bioRxiv publishes preliminary scientific reports that are not peer-reviewed and should therefore not be considered conclusive, guide clinical practice / health-related behavior, or treated as established information

Tags: ACE2, angiotensin, angiotensin converting enzyme 2, antibody, binding affinity, cell, coronavirus, coronavirus disease COVID-19, enzyme, genetics, immune system, medicine, mutation, protein, public health, receptor, research, Respiratory system, SARS, SARS-CoV-2, severe acute airway, severe acute respiratory syndrome, syndrome

Jocelyn Solis-Moreira graduated with a bachelor’s degree in integrative neuroscience and then did research on the long-term effects of excessive alcohol in adolescents on the neurochemistry of the brain in adulthood

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News – AU – UK and South African SARS-CoV-2 variants show higher binding affinity to the host cell receptor

Source: https://www.news-medical.net/news/20210224/UK-and-South-African-SARS-CoV-2-variants-show-higher-binding-affinity-to-host-cell-receptor.aspx